Superchargingimmunity

Powerhouse Therapeutics is a biotechnology company focused on developing cell therapies that help patients fight the deadliest cancers.

Our Breakthrough Platform

At the forefront of precision medicine, our Immune Triad Therapy with Armed CAR T-cell Supercharger (IT-ACTS) platform is a proprietary 'living drug' designed for targeted delivery of immune superchargers.

Unlike conventional therapies, IT-ACTS uniquely disrupts multiple resistance and evasion mechanisms simultaneously, while reprogramming the tumor immune microenvironment.
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Explore our core technology

Our Flagship Therapy: PH102

Pioneering Solid Tumor Therapies
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Our flagship candidate, PH102, is a GPC3-targeted IT-ACTS therapy engineered to revolutionize solid tumor treatment, particularly for challenging liver cancer (hepatocellular carcinoma). It uniquely overcomes immunotherapy resistance through a novel triple-action platform that significantly enhances immune cell activity and boosts tumor infiltration.

Preclinical studies demonstrate exceptional, durable anti-tumor responses with unprecedented persistence and superior safety, even from a single dose. PH102 represents a first-in-class approach, offering a compelling new avenue for combating hard-to-treat cancers where other treatments have failed.

Learn more about PH102

Discover Our Advancing Pipelines

Solid Tumors

Our solid tumor pipeline harnesses the modular IT-ACTS platform to engineer multi-armed, tumor-killing cells that safely dismantle resistance pathways across hard-to-treat cancers while building immune memory. The pipeline spans both autologus and allogeneic (off-the-shelf) programs.

Fibrotic Disease

Our fibrotic-disease pipeline uses our living-drug engineering to reprogram immune and stromal crosstalk driving pathological scarring. First-in-class candidates target key pro-fibrotic cells, aiming to halt progression and promote tissue regeneration with applications in trauma and liver disease.

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Explore the latest advancements from Powerhouse Therapeutics.

AACR Annual Meeting 2025

News

4/10/2025

San Antonio Liver Cancer Symposium 2024

News

9/30/2024

Synergy Grant to Dr. Gang Huang

News

9/1/2023

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Committed to Patients & Their families

Our world-class team is dedicated to pushing the boundaries of innovation, developing therapies that not only extend lives but also improve quality of life.

Meet the team

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"We are spearheading advances in cell and gene therapy, translating discovery into high-impact solutions that redefine precision medicine's possibilities and give new hope to all patients."

Vincent Pham

Co-Founder and CEO